The exercise was carried out with the aim to enhance response capabilities for the upcoming summer, amid growing risk associated with climate change and the potential for large-scale wildfires.
The fire began on Monday near Kibbutz Kalia, north of Israel's Dead Sea.
Thirteen injured people with varying degrees of injury, three of which were in moderate condition, were evacuated to medical centers in Haifa.
Four major fires broke out across Israel on Monday, with dozens of firefighting teams and multiple planes fighting against the flames.
The children from the Israeli Bedouin town of Tel Sheva were hurried to the hospital in serious condition but died there shortly after.
No foul play was suspected.
Firefighters were continuing to tackle the blaze and 80 people have been evacuated, according to the rescue services.
Ram Ben Barak's Moshav Nahalal barn burned down overnight, and electrical malfunctions have been ruled out as the cause.
REPORTER'S NOTEBOOK: The shops along the stretch of the road, including dozens of groceries, butchers and car shops, were all shuttered, many sporting scorch marks from the violence overnight.
The storm that will reach Israel on Monday morning caused extensive preparations by the country's rescue services and municipalities.